P-Shot: How PRP Boosts Erectile Function

Current research shows that PRP intracavernosal injections are considered experimentally safe, with few adverse events (such as mild pain or bruising at the injection site) reported in studies. Some small studies and clinical trials suggest modest improvements in erectile function for certain men—especially those with arteriogenic (blood vessel-related) erectile dysfunction. 

The science behind the P-Shot centers on using platelet-rich plasma (PRP), a substance derived from the patient’s blood rich in platelets and growth factors. When injected into the penis, these growth factors are believed to stimulate tissue repair, new blood vessel formation (angiogenesis), and nerve regeneration. The primary mechanisms proposed include:

• Release of Growth Factors: Upon injection, activated platelets release growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF). These molecules are crucial in promoting angiogenesis, recruiting stem cells, stimulating cell proliferation, modulating inflammation, and supporting tissue regeneration.
• Tissue Repair and Angiogenesis: PRP is thought to aid repair by increasing cell numbers (mitogenesis) and encouraging new blood vessel growth. This can improve blood flow in the erectile tissue—an essential factor for healthy erections15. VEGF, for instance, supports endothelial cell proliferation and enhanced vascularity, which are critical for erectile function.
• Neuroprotective and Neurotrophic Effects: Preclinical studies indicate that PRP can enhance nerve healing by promoting axon myelination, reducing nerve cell death (apoptosis), and supporting nerve fiber regeneration. This is particularly relevant in cases of nerve-related erectile dysfunction, such as after prostate surgery.
• Experimental and Restorative Effects: In addition to symptomatic relief, PRP is being studied for its potential to restore normal function by directly targeting the underlying causes of erectile dysfunction, such as vascular or nerve damage. Early clinical trials report promising but modest improvements, especially among men with arteriogenic (blood vessel–related) erectile dysfunction. However, the effects tend to decline over time, and no standardized protocol for PRP preparation or administration is currently available.

The procedure is generally considered safe, with mild side effects, but the clinical evidence remains preliminary. Larger, high-quality, randomized trials are still needed to fully validate these mechanisms and clarify who benefits most from the P-Shot.

In summary, the P-Shot (PRP therapy for ED) works by delivering growth factors that drive blood vessel and nerve repair in penile tissue, which may improve erections by addressing underlying vascular and neurological factors.